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M94A3142.TXT
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1994-10-25
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Document 3142
DOCN M94A3142
TI Does Pneumocystis carinii prophylaxis modify the clinical and biological
AIDS presentation? Results of the Bordeaux Hospital cohort (France,
1985-1993). The GECSA.
DT 9412
AU Morlat P; Hubert JB; Chene G; Dequae L; Vimart E; Dabis F; Hopital
Saint-Andre, INSERM U.330, Bordeaux, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):144 (abstract no. PB0004). Unique
Identifier : AIDSLINE ICA10/94369433
AB OBJECTIVES: To compare the clinical and immunological features at time
of AIDS diagnosis in patients who received Pneumocystis carinii (P.c.)
prophylaxis (P+) and in those who did not (P-). METHODS: From 1985 to
September 1993, data on 3117 HIV-infected patients have been
prospectively recorded in a hospital-based surveillance system. The
study was limited to incident AIDS cases (patients included in the
cohort before the diagnosis of AIDS). AIDS was defined according to the
1987 CDC definition. Measurement of CD4 lymphocyte count (CD4+) was done
at time of AIDS diagnosis. A patient was considered to have received
P.c. prophylaxis if such treatment was reported at any visit before the
diagnosis of the initial AIDS-related illness. RESULTS: 523 of the 1004
AIDS cases reported were incident cases. CD4+ were measured in 396
patients. TABULAR DATA, SEE ABSTRACT VOLUME. CONCLUSION: Mean CD4+ count
at time of AIDS diagnosis was significantly lower (p < 0.01) in patients
who received P.c. prophylaxis. This suggest that P.c. prophylaxis (and
possibly the early use of zidovudine) delays the onset of the initial
AIDS-related illness. The avaibility of a specific prophylaxis allowed a
decrease in the occurence of P.c. pneumonia; nevertheless P.c. pneumonia
remained frequent. In addition to research on prevention against other
opportunistic infections, efforts should still be carried on to improve
compliance and efficiency of the P.c. prophylaxis.
DE Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/IMMUNOLOGY/
*PHYSIOPATHOLOGY AIDS-Related Opportunistic Infections/*PREVENTION &
CONTROL Cohort Studies Comparative Study France Human Incidence
Leukocyte Count Pneumocystis carinii Infections/*PREVENTION & CONTROL
Prospective Studies T4 Lymphocytes/IMMUNOLOGY Zidovudine/THERAPEUTIC
USE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).